Finally, acantholysis with minimal dyskeratosis can be seen, as an incidental phenomenon, in other disease processes such as pityriasis rubra pilaris and seborrheic keratoses Histopathology confirms acantholysis, with or without dyskeratosis (Figure 2). Ralph Grover himself would confirm the diagnosis by documenting acantholytic and dyskeratotic cells, including classical corps ronds and grains, in cytologic preparations (Tzank smear) Hailey-Hailey-like: suprabasal acantholysis of all levels of the epidermis without significant dyskeratosis (dilapidated brick wall appearance) More than one pattern can be seen in the same setting Other newly described histopathological pattern include: ( Am J Dermatopathol 2010;32:541
One case of seborrhoeic keratosis with extensive acantholysis and moderate dyskeratosis is reported. The histological features ressembled those of Darier and Hailey-Hailey diseases. Another seborrhoeic wart simultaneously removed had no microscopic abnormalities Transient acantholytic dermatosis is usually diagnosed clinically, but a skin biopsy may be necessary. The pathology of transient acantholytic dermatosis is characteristic, with acantholysis (separated skin cells) with or without dyskeratosis (abnormal rounded skin cells). Spongiotic dermatitis may also be noted Dyskeratosis follicularis like changes are reported on a pigmented intradermal naevus (follicular infundibulum) from the nose of a 23 years old woman with no other stigmata of Darier's disease. These findings are discussed at the light of Ackerman's concept of focal acantholytic dyskeratosis and the relevant literature is reviewed
Acantholytic acanthoma was originally described as a solitary lesion displaying histologic features of acantholysis without dyskeratosis. Solitary, non-genital lesions displaying confluent. Hyperkeratosis and dyskeratosis are more pronounced in DD, and there is no extensive acantholysis similar to that found in PAD. Grover disease has a sudden onset, manifesting as pruritic red papulovesicles, which are common on the neck, trunk, and proximal limbs but have not been reported in the anogenital area. [6 History revealed that the disease had only been present for a few years. A skin biopsy showed focal suprabasal acantholysis, dyskeratosis up to the horny layer and in part parakeratotic hyperkeratosis. The patient had no further evidence for Darier disease, Hailey-Hailey disease or pemphigus vegetans The sections were stained with hematoxylin-eosin and periodic acid-Schiff. Serial and step sections showed very characteristic changes. On one side of the lesion, there was an angled indentation of the epidermis with marked dyskeratosis and acantholysis of the keratinocytes in the bottom (Fig 2, A).In particular, some very large acantholytic dyskeratotic cells with hyperchromatic nuclei and.
Acantholytic and Acantholytic Dyskeratotic Acanthoma Christine J. Ko, MD Key Facts Clinical Issues Generally a solitary papule Often on trunk Often submitted as rule out basal cell carcinoma Microscopic Pathology Flat, plaque-like architecture Minimal to no cytologic atypia Acantholytic acanthoma Acantholysis without dyskeratosis Acantholytic dyskeratotic acanthoma Acantholysis with. L11.8 is a billable diagnosis code used to specify a medical diagnosis of other specified acantholytic disorders. The code L11.8 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code L11.8 might also be used to specify conditions or terms like. There were no lesions at other locations. A histological examination showed hyperkeratosis and parakeratosis, suprabasilar and intraspinous acantholysis, and dyskeratotic cells resembling corps ronds (Fig. 1c). Based on these findings, we made a diagnosis of PAD of the genital area
Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months Histologically, the biopsy specimen showed acantholysis throughout the epidermis with the presence of dyskeratotic cells resembling corps ronds and grains, hyperkeratosis and parakeratosis. These clinical and histological findings were consistent with the diagnosis of papular acantholytic dyskeratosis of the vulva which is a rare disorder. INTRODUCTIONFocal acantholytic dyskeratosis is a term that is often used both for clinically inapparent incidental foci and for clinically apparent solitary lesions with the histological pattern of acantholytic dyskeratosis. 1 It is characterized by hyperkeratosis and parakeratosis with intraepidermal clefts harboring acantholytic and dyskeratotic keratinocytes with the formation of corps.
healthy with no family history of similar condition. Microscopic examination of one papule demonstrated a cup-shaped invagination with keratotic plug, dyskeratosis, suprabasal acantholysis with prominent villi (Figure 2) and mild dermal lymphocytic infiltrate. Figure 2:Comedonal Darier's disease: Histopathological finding Focal acantholytic dyskeratosis (FAD), epidermolytic hyperkeratosis (EHK), and Hailey-Hailey-like acantholysis (HH) represent unique histology reaction patterns, which can be associated with defined phenotypic and genotypic alterations. Incidental microscopic foci demonstrating these patterns have been identified in skin and mucosal specimens in association with a gamut of disease processes Acantholytic disorder, unspecified. 2016 2017 2018 2019 2020 2021 Billable/Specific Code. L11.9 is a billable/specific ICD-10-CM code that can be used to indicate a. Acantholysis, with little or no dyskeratosis, can be seen as an incidental phenomenon 1009 or as a solitary tumor of the skin - acantholytic acanthoma (see p. 672 ). 1010,1011 This pattern has also been found in multiple papules 1012 and as a variant of epidermal nevus with horn-like processes Pemphigus causes blisters on your skin and mucous.
Acantholysis in PRP may predate the development of charac-teristic histopathological features, often leading to the incorrect diagnosis of a primary acantholytic disease.7 No association between the presence of acantholysis and disease severity has been reported. Bullous impetigo Impetigo is a contagious superﬁcial pyoderma, most com . We present a patient who developed an acantholytic dyskeratotic acanthoma and summarize the acantholytic.
Acantholysis is noted only at the granular layer in pemphigus foliaceus (Fig. 4.9). The characteristic cell is a dyskeratotic granular layer cell. In some cases there is a mid-epidermal cleft with acantholytic cells. However, there is no evidence of suprabasilar acantholysis, ruling out a variant of pemphigus vulgaris Grover's disease is a relatively common, itchy skin condition, predominantly affecting the trunk in middle-aged or elderly people. Although it is referred to as ''transient'', symptoms can be more persistent Acantholytic dyskeratosis is characterized by the presence of suprabasal acantholysis along with acantholytic and dyskeratotic cells. This reaction pattern is seen in a variety of conditions with varied clinical presentations. Darier's disease There is epidermal hyperkeratosis with a suprabasal cleft with areas of acantholysis a. Dyskeratotic Dyskeratosis: abnormal, premature keratinization of keratinocytes below granular cell layer; often have brightly eosinophilic cytoplasm Epidermolysis: alteration of granular layer with perinuclear clear spaces, swollen and irregular keratohyalin granules, increased thickness of granular layer; different from acantholysis Grover's disease (GD), also known as benign papular acantholytic dermatosis, transient acantholytic dermatosis, and persistent acantholytic dermatosis is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis:529 with or without dyskeratosis
Galli-Galli disease (GGD) is a very rare variant of the Dowling-Degos disease (DDD) with the histologic finding of focal acantholysis. It was originally reported by Bardach et al. in 1982, who described the disease in two brothers and named it eponymically after this family [ 1 On one side of the lesion, there was an angled indentation of the epidermis with marked dyskeratosis and acantholysis of the keratinocytes in the bottom (Fig 2, A).In particular, some very large acantholytic dyskeratotic cells with hyperchromatic nuclei and. Galli-Galli disease (GGD) is a very rare variant of the Dowling-Degos disease (DDD.
Histopathological changes include acantholysis with variable degrees of dyskeratosis, and direct and indirect immunofluorescence have been negative in almost all cases studied. 5. We present a 58-year-old woman with no past medical history or family history of interest With respect to acantholytic disorders, identify 3 genodermatoses that result in acantholysis and the mutated gene in each: 1) Darier disease (ATP2A2) 2) Hailey-Hailey disease (ATP2C1) 3) Galli-Galli disease (Keratin 5) What layer of the epidermis is each of the following typically found: (1) Grains (2) Corps ronds 1. Grains = Stratum corneum 2. Corps ronds = Granular layer (Meg note: Bolognia. Histopathologic examination of a plantar lesion showed hyperkeratosis without dyskeratosis or acantholysis, whereas a skin biopsy specimen showed a suprabasilar split with dyskeratotic and acantholytic cells. These case reports illustrate the unusual variations of palmoplantar lesions that can be associated with keratosis follicularis . 1. Ackerman AB. Focal acantholytic dyskeratosis. Arch Der-matol 1972;106:702-706. 2. Hutcheson AC, Nietert PJ, Maize JC. Incidental epidermolytic hyperkeratosis and focal acantholytic dyskeratosis in com-mon acquired melanocytic nevi and atypical melanocytic lesions. J Am Acad Dermatol 2004;50:388-390. 3. Hutcheson AC, Nietert PJ, Maize JC
SUMMARY We describe a 33‐year‐old man with an unusual epidermal naevus that followed the lines of Blaschko. There were filiform hyperkeratoses, large cutaneous horns and lesions that resembled giant comedones and linear hyperkeratotic plaques. All of these lesions showed acantholysis without dyskeratosis. As the disorder is characterized by multiple small or large horn‐like processes, we. . The origin of GD is unknown. Suggested causes include sweating, heat, immobilization occlusion, external beam and ultraviolet radiation, and xerosis Transient acantholytic dermatosis (Grover disease) is not an uncommon condition, but, surprisingly, it was not thoroughly characterized until Grover did so in 1970. While generally accepted to be a benign, self-limited disorder, it is often persistent and difficult to manage; hence, the description of transient is misleading Hereditary Benign Intraepithelial Dyskeratosis (HBID) is a benign disease of the conjunctiva, cornea, and oral mucosa. HBID follows a Mendelian autosomal dominant inheritance pattern with high penetrance. Due to the classic sign of marked, bilateral conjunctival hyperemia, this disease is sometimes referred to as the red eye disease
, The acantholysis in Grover's disease is often focal and may be missed unless several sections are examined.  Although Grover's disease has been commonly reported in the western literature, it seems to be distinctly uncommon in the Indian subcontinent and we could find no reports of Grover's disease in Indian journals devoted to dermatology an electron microscopic study of acantholysis and dyskeratosis in pemphigus foliaceus: with a special note on peculiar intracytoplasmic bodies. wilgram gf, caulfield jb, madgic eb. the journal of investigative dermatology, 01 nov 1964, 43: 287-299 doi: 10.1038/jid. age. However, most studies show no statistically increased Figure 4: Incidental focus of Hailey-Hailey-like acantholysis, occurring in association with a benign keratosis with features of seborrheic keratosis. (200X magniﬁcation, hematoxylin, and eosin stain). incidence in sun-exposed versus non-sun-exposed skin for these incidental changes
The ATP2C1 gene encodes a Golgi associated Ca-ATPase (SERCA2), which is responsible for the Ca content in the Golgi apparatus. A decrease of the Ca level leads to defective processing of different adhesion molecules (E-cadherin), insufficient cell-to-cell adhesion and acantholysis. S.a.u. Dyskeratosis follicularis Histopathologically, focal acantholysis and dyskeratosis is seen as well as occasional spongiosis. (neurologyadvisor.com) Histopathologic findings include multiple areas of suprabasilar acantholysis with dyskeratosis, corps ronds and columns of parakeratosis (grains). (neurologyadvisor.com Papular acantholytic dyskeratosis (PAD) of the vulva, first described in 1984 by Chorzelski et al., 1 mainly affects young women, typically on the labia majora, although it has also been described on the penis in men, in the anal canal, and in the inguinal folds. 2,3 It usually presents as multiple whitish papules that may coalesce to form plaques; solitary papules are rare There was no family history of skin diseases. Histologically, cutaneous and mucosal specimens were characterized by acantholytic and dyskeratotic cells, corps ronds and grains in the parakeratotic zone, and by hyperkeratosis and parakeratosis. A diagnosis of epidermal naevus with acantholytic dyskeratosis was made
We report a patient with focal acantholytic dyskeratosis occurring on both the upper lip and the anal canal. Histopathologically, the lesions showed hyperkeratosis, suprabasilar clefting, epidermal acantholysis and dyskeratosis. This case represents the first report of a focal acantholytic dyskeratosis occurring on both the lip and the anal canal Hyperkeratosis, acantholysis, dyskeratosis, and suprabasilar clefts were also focally present. Correlation of the lesion's clinical morphology and microscopic features established a diagnosis of trichofolliculoma with incidental focal acantholytic dyskeratosis. Hence, trichofolliculoma can be added to the list of follicular lesions in which. INTRODUCTION. Darier's disease (DD), described independently by Darier and White in 1889, is an autosomal-dominant disease characterized by persistent eruption of hyperkeratotic papules, histological examination of which shows suprabasal acantholysis with distinct overlying dyskeratosis. Expressivity is variable but the penetrance is complete in adults.[ No acantholysis was seen. There was irregular thinning of the epidermis and dyskeratosis was observed at places [Figure 3] . A mild chronic inflammatory infiltrate was seen in upper dermis with melanin
Typically, focal acantholysis and dyskeratosis are seen. Spongiosis is also commonly observed, and the presence of spongiosis, acantholysis, and vesicle formation in the same specimen should raise. . Dyskeratotic cells are referred to as corps ronds and grains. A central keratin-filled invagination may be identified Acantholytic dyskeratosis of the genitocrural area is a rare lesion included in the spectrum of focal acantho-lytic dyskeratoses described by Ackerman. 19. It also has been referred to as papular acantholytic dyskeratosis of the vulva, though histologically similar lesions also have been reported in men. 20-22. Histologically, acantholyti Grover's diseaseis an itchy acantholytic disorder occurring on the trunk of middle-aged men. It is a transient dermatosis of unknown cause manifesting clinically as a papular skin eruption located usually on the anterior chest and abdomen and histologically with dyskeratosis and acantholysis. This disease has occasionally been reported in patients with chronic renal failure, some infections.
The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well. In this study of 120 consecutive cases of GD, we have found a sex and age incidence similar to. Lesions are usually present for a long duration with no antecedent family history. Females are usually affected with the labia majora being the most common site involved. Only a few cases have been reported in males. Histopathology shows features of acantholysis accompanied by varying degrees of dyskeratosis The clinical and histopathological diagnosis of pityriasis rubra pilaris (PRP) can be difficult because clinical findings are often subtle in early stages, and microscopic findings can overlap with those of other skin diseases. Focal acantholytic dyskeratosis (FAD) can rarely be seen in PRP and can mimic Darier's disease, Grover's disease or other disorders characterized by these. Keywords: Acantholysis, Male, Perineum. 關鍵詞: 棘層松解、男性、會陰. Introduction. Papular acantholytic dyskeratosis of the genitocrural area (PADGA) was first reported in 1977 in a female. 1 Since then, many cases have been reported and predominantly in females. No cases have been reported in Hong Kong so far Multilinear separate areas delineated by a band of unaffected skin were apparent. She had no nail or oral mucosal abnormalities. Results of a biopsy of mid and left lower abdominal lesions showed foci of suprabasilar acantholysis and dyskeratosis including both corps ronds and grains (Figure 2)
Acantholysis therefore occurs right above the basal cell layer, forming suprabasilar vesicles.11, 12 PV is divided in both, humans and dogs, in a mucosal-dominant type and a mucocutaneous type. In the mucosal-dominant type oral lesions dominate with little or no skin involvement, whereas in th Acantholytic keratinocytes may be present in lower. eruption characterized histopathologically by acantholysis with or without dyskeratosis. The origin of GD is unknown. Suggested causes include sweating, heat, immobilization occlusion, external beam and ultraviolet radiation, and xerosis. GD has also been found to occur in association with other diseases
The Hailey-Hailey-like pattern consists of subrabasal acantholysis of all levels of the epidermis without significant dyskeratosis—the so-called dilapidated brick wall appearance . The pemphigus vulgaris-like pattern appears as predominantly and limited to suprabasal acantholysis, with the basal keratinocytes remaining attached to the. Acantholysis was absent and dyskeratosis was observed at some places (Figs. 3a and 3b). Figure 3: (a) Crater-like epidermal invagination containing plugs of lamellar keratinous materials. (b) Acantholysis was absent and dyskeratotic cells were seen (downward black arrow- grains with elongated nucleus and pointer showing corps rond). (H & E, x 40) ADEN is a subtype distinguished by its Darier-like pattern of acantholysis and dyskeratosis. 1 Distinguishing between ADEN and DD relies on clinical-pathologic correlation. Both demonstrate histologic loss of adhesion between suprabasal keratinocytes (acantholysis), abnormal keratinization (dyskeratosis) in the form of corps ronds and. Direct immunotluorescence was negative with no depo-sition of immunoglobulins or complemetit iti the skin. Electron micwscopii This was performed only on the vulval lesions and the ultrastructural changes were those of acantholysis and dyskeratosis. There was a total disappearance of intercel-lular connections and the number of desmosome
Acantholysis with dyskeratosis is the histological hallmark of the disease. A variation in features has led to 4 classically recognized patterns of acantholysis in GD: Darier like, Hailey-Hailey like, pemphigus like, and spongiotic. Additional patterns have been proposed recently, including porokeratotic,. acantholysis. Web. Medical Information Search. Disuse atrophy of muscles and bones, with loss of mass and strength, can occur after prolonged immobility, such as extended bedrest, or having a body part in a cast (living in darkness for the eye, bedridden for the legs etc.) Histologic examination disclosed focal acantholysis with dyskeratosis. The lesions were clinically and histologically indistinguishable from those of Grover's disease. A possible association with Grover's disease and chronic renal failure and/or hemodialysis is postulated. Possible implicated pathogenic mechanisms are discussed
Acantholysis. Acantholysis is the loss of cohesion between epidermal (or epithelial) cells leading to the formation of intraepidermal clefts, vesicles, or bul-lae. Primary acantholysis results from dissolution or separation of the desmosomes between unaltered cells. Secondary acantholysis occurs between damaged cells such as during viral. No systemic symptoms are associated with transient acantholytic dermatosis (Grover disease), but oral lesions can develop that resemble aphthae and may be slightly painful. Typically, focal acantholysis and dyskeratosis are seen. Spongiosis is also commonly observed, and the presence of spongiosis, acantholysis, and vesicle formation in the.
Massive acantholysis of the epidermis with a typically spared hair follicle. (H&E, 60x) Figure 3. Detail on acantholytic epidermis with dyskeratotic keratinocytes and parakeratosis. (H&E, 80x) A 40-year-old woman was referred by her dermatologist to a surgeon in order to perform an incisional biopsy of the pathologic skin lesion. At tha A biopsy of the oesophageal lesions showed an intraepithelial cleft with acantholysis, but without dyskeratosis, along with a limited inflammation in the underlying chorion, overall reminiscent of specific lesions of HHD. The patient had no history of gastrointestinal reflux and is not known as smoker or alcohol consumer Acantholysis and dyskeratosis (abnormal keratinization) are the 2 main features of Darier disease. Loss of epidermal adhesion with acantholysis frequently results in the formation of suprabasal. Because within an acanthotic epidermis there is only focal suprabasal acantholysis and dyskeratosis but no extensive epidermal acantholysis with the dilapidated brick wall appearance. There are something else in the upper part of the epidermis: keratinocytes with steel ‐grey nuclei and syncytia
on the histopathological findings (acantholysis with dyskeratosis) and the clinical picture, the diagnosis of Grover's disease was made. UVB-NB phototherapy was initiated, but it was later withdrawn, as there was no possibility to continue it in the outpatient setting. Therapy with acitretin at 25 mg/day (0.4 mg/kg bw The 2021 edition of ICD-10-CM L11 became effective on October 1, 2020. This is the American ICD-10-CM version of L11 - other international versions of ICD-10 L11 may differ. viral warts ( B07.-) Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes The acantholysis was observed after only a 12-h incubation and was most marked after a 24-h or 48-h incubation. Following this, the histological change was gradually replaced by the degenerative change of keratinocytes. On the other hand, once the degenerative change was marked, no acantholysis was observed for up to 4 days of culture (Figures Dyskeratosis of the Face: A Comment. Acta Derm Venereol. Diagnosis: Pemphigus vegetans. The patient's facial appearance after imiquimod application is shown in Fig. 2A. New biopsy from the cheek showed more pronounced suprabasal acantholysis with slight dyskeratosis in a hyperplastic epidermis (not shown). Direct immunofluorescence on.
The result is a loss of suprabasilar cell adhesion (acantholysis) and an induction of apoptosis (dyskeratosis). History In 1889, the French dermatologist Jean Darier , at the Hôpital Saint-Louis in Paris, and James C White , Professor of Dermatology at Harvard University, independently reported a skin disease characterized by brown, crusted. subcorneal split with acantholysis, dyskeratosis within granular layer, neutrophils in vesicles. Sneddon-Wilkinson Disease. Subcorneal pustule filled with neutrophils, no dyskeratosis, superficial mixed perivascular infiltrate. Acute generalized exanthematous pustulosis The most common and distinctive histologic manifestation of WD is a cup-shaped lesion filled with a parakeratotic plug, although the lesions may also be cystic or nodular (28). The proliferating cells of the lesion show dyskeratosis and suprabasal acantholysis and may resemble koi-locytes In DD, GD and HH, the number of TUNEL-stained keratinocytes was lower, apoptotic keratinocytes were confined to the regions of dyskeratosis and acantholysis, and pyknosis was absent. In conclusion, disruption of cell-cell contacts in acantholytic skin disorders may in some cases cause apoptosis of keratinocytes
Another variant of Grover disease has a Hailey-Hailey-like pattern, which is characterized by Hailey-Hailey disease's dilapidated brick wall appearance or the diffuse suprabasal acantholysis of all epidermal layers without notable dyskeratosis. 4 Hailey-Hailey disease, also known as familial benign pemphigus, is an autosomal-dominant disorder that presents with erythematous vesicular plaques. Both diseases are characterized histologically by the breakdown of intercellular contacts between suprabasal keratinocytes (acantholysis) with variable dyskeratosis. Differential diagnosis is based on the skin lesion types, their distribution on the body, and subtle histological differences [ 9 , 11 , 12 ]
Transient acantholytic dermatosis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now Dyskeratosis congenita can have different inheritance patterns. When dyskeratosis congenita is caused by DKC1 gene mutations, it is inherited in an X-linked recessive pattern.The DKC1 gene is located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition Several previous studies have reviewed incidental foci of FAD, HH, or EHK. In the largest studies, incidental acantholysis was identified in 14 of 9000 specimens , and incidental FAD was identified in 8 of 5800 skin specimens .Incidental EHK was identified in 21 out of approximately 30,000 specimens  and 41 out of 21,176 consecutive specimens 
PDF | HTML | XML - Hailey-Hailey Disease: A Challenging Diagnosis in Biopsy Practice | Find, read and cite all the research you need on IARCorsortiu He had no other oral ulcers or skin lesions. A skin biopsy was performed and histopathologic examination revealed suprabasal acantholysis with associated overlying dyskeratosis, consistent with Grover's disease (Fig. 1a-c). The acantholysis extended to the spinous layer of the epidermis with some keratinocytes retaining partial attachment to. Acantholysis, with little or no dyskeratosis, can be seen as an incidental phenomenon 1009 or as a solitary tumor of the skin - acantholytic acanthoma (see p. 672 ). 1010,1011 This pattern has also been found in multiple papules 1012 and as a variant of epidermal nevus with horn-like processe Dyskeratosis and acantholysis on histopathology characterize Darier disease. Dyskeratosis is premature keratinization of keratinocytes and is related to apoptosis. In Darier disease, this is seen as corps ronds. Corps ronds are round keratinocytes with basophilic nuclei. Acantholysis means a loss of adhesion between cells
Subcorneal split with some acantholysis and dyskeratosis. Net-like IgG/C3 in upper epidermisNet-like IgG/C3 in upper epidermi Figure 2: A biopsy showing focal acantholytic dyskeratosis, focal suprabasal acantholysis, and intense inflammatory infiltrate, composed mainly of lymphocytes, in the papillary dermis (H&E, 100×). Systemic and topical steroids reduced the lesions and the patient was instructed to avoid such predisposing factors as heat, excessive sweating, and. Grover disease (GD), also referred to as transient or persistent acantholytic dermatosis, is an acquired pruritic papular or papulovesicular eruption characterized histopathologically by focal acantholysis and dyskeratosis Acantholysis. Acantholysis is the loss of cohesion between epidermal (or epithelial) cells leading to the formation of intraepidermal clefts, vesicles, or bul-lae. Primary acantholysis results from dissolution or separation of the desmosomes between unaltered cells. Secondary acantholysis occurs between damaged cells such as during viral infection
¥ The histologic DDx of focal acantholysis +/-dyskeratosis ¥ Keratin 5 mutations are found in Galli-Galli, Dowling-Degos, and EBS with mottled hyperpigmentation References Bardach H, Gebhart W, Luger T. Genodermatosis in a pair of brothers: Dowling-Degos, Grover, Darier, Hailey-Hailey, or Galli-Galli disease? Hautarzt 1982; 33(7): 387-83 Histopathologic examination showed acantholysis and dyskeratosis, which was consistent with Darier-White disease. Darier-White disease is a rare, hereditary disorder that is inherited in an autosomal dominant manner and that usually presents in adolescence or early adulthood due to mutations in the SERCA2 calcium pump unaffected skin were apparent. She had no nail or oral mucosal abnormalities. Results of a biopsy of mid and left lower abdominal lesions showed foci of suprabasilar acantholysis and dyskeratosis including both corps ronds and grains (Figure 2). The patient was given a midpotency topical steroid to use as needed for the pruritus; she declined. Practical examples. Automatically generated examples: Hereditary benign intraepithelial dyskeratosis is a rare type of genodermatosis that may occur in infancy and early childhood, its symptoms often appear in the patients' eyes and mouths. Genodermatosis - Wikipedia Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis. Journal of Cutaneous Pathology, vol. 21, no. 5, 1994, pp. 453-6. Wong KT, Wong KK. A case of acantholytic dermatosis of the vulva with features of pemphigus vegetans Focal acantholytic dyskeratosis has been described as an incidental finding and as a clinically distinct lesion. In both situations, a dimorphic histologic pattern is observed: acantholysis and dyskeratosis. Solitary, non-genital lesions displaying such pathology have been difficult to classify. Clinical and pathological characteristics of acantholytic dyskeratotic acanthomas are described